diff --git a/toolchain/check/cpp/import.cpp b/toolchain/check/cpp/import.cpp
index c9340d6ff404..12189c74b3c8 100644
--- a/toolchain/check/cpp/import.cpp
+++ b/toolchain/check/cpp/import.cpp
@@ -2264,6 +2264,10 @@ static auto MapConstant(Context& context, SemIR::LocId loc_id,
         MakeStringLiteral(context, Parse::StringLiteralId::None, string_id);
     context.imports().push_back(inst_id);
     return inst_id;
+  } else if (isa<clang::CXXNullPtrLiteralExpr>(expr)) {
+    auto type_id = MapNullptrType(context, loc_id).type_id;
+    return GetOrAddInst<SemIR::UninitializedValue>(context, SemIR::LocId::None,
+                                                   {.type_id = type_id});
   }
 
   SemIR::TypeId type_id = MapType(context, loc_id, expr->getType()).type_id;
diff --git a/toolchain/check/cpp/macros.cpp b/toolchain/check/cpp/macros.cpp
index 9b8cbea67670..9684f4c7a9e0 100644
--- a/toolchain/check/cpp/macros.cpp
+++ b/toolchain/check/cpp/macros.cpp
@@ -62,7 +62,8 @@ auto TryEvaluateMacroToConstant(Context& context, SemIR::LocId loc_id,
   }
 
   if (isa<clang::StringLiteral>(result_expr) ||
-      isa<clang::CharacterLiteral>(result_expr)) {
+      isa<clang::CharacterLiteral>(result_expr) ||
+      isa<clang::CXXNullPtrLiteralExpr>(result_expr)) {
     return result_expr;
   }
 
diff --git a/toolchain/check/testdata/interop/cpp/macros.carbon b/toolchain/check/testdata/interop/cpp/macros.carbon
index eeaa6ab2fc4b..141331152f3d 100644
--- a/toolchain/check/testdata/interop/cpp/macros.carbon
+++ b/toolchain/check/testdata/interop/cpp/macros.carbon
@@ -2,7 +2,7 @@
 // Exceptions. See /LICENSE for license information.
 // SPDX-License-Identifier: Apache-2.0 WITH LLVM-exception
 //
-// INCLUDE-FILE: toolchain/testing/testdata/min_prelude/primitives.carbon
+// INCLUDE-FILE: toolchain/testing/testdata/min_prelude/full.carbon
 //
 // AUTOUPDATE
 // TIP: To test this file alone, run:
@@ -595,6 +595,20 @@ fn F() {
  Cpp.M_TRUE = false;
 }
 
+// --- nullptr.carbon
+
+library "[[@TEST_NAME]]";
+
+import Cpp inline '''
+  #define MyNullPtr nullptr
+  void foo(int arr[2]);
+''';
+
+fn F() {
+  Cpp.foo(Cpp.MyNullPtr);
+}
+
+
 // --- lambda.carbon
 
 library "[[@TEST_NAME]]";